Use of non-subtype B gag proteins for lentiviral packaging
AssigneesTheravectys, Institut Pasteur
InventorsThi-Lan Tran, Pierre Charneau, Cecile Bauche
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Abstract
The invention encompasses a lentiviral packaging vector comprising a non-subtype B gag-pol sequence, particularly a subtype D gag-pol sequence. The invention further encompasses methods for making and using these vectors. The invention further encompasses lentiviral vector particles comprising HIV-1 non-subtype B Gag and/or Pol proteins.
Claims13
A lentiviral packaging vector to generate a replication defective lentiviral vector particle, the vector lacking a site and encoding the Gag-Pol protein of HIV-1 NDK, wherein the Gag-Pol protein comprises the amino acid sequence of SEQ ID NO:2 wherein the coding sequence of the Gag-Pol protein is operably linked to an expression control sequence.
A lentiviral vector particle comprising Gag-Pol protein of HIV-1 NDK and VSV Env glycoproteins, wherein the Gag-Pol protein comprises the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.