RNAi-mediated inhibition of connexin 43 for treatment of IOP-related conditions
AssigneeArrowhead Pharmaceuticals, Inc.
InventorsJon E. Chatterton, Abbot F. Clark, Martin B. Wax
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Abstract
RNA interference is provided for inhibition of connexin 43 (Cx43) in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma.
Claims21
An interfering RNA for inhibiting the expression of a connexin 43 (Cx43) gene, wherein the interfering RNA comprises a sense strand and an antisense strand each 19-49 nucleotides in length, wherein the sense strand comprises a nucleotide sequence of SEQ ID NO:13, except that each T can be independently replaced with a U, and the antisense strand comprises a nucleotide sequence that is complementary to the sense strand.
Dependencies are inferred from the claim text.