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US 9,752,146 B2Granted
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
AssigneeRegulus Therapeutics Inc.
InventorsC. Frank Bennett, Susan M. Freier, Richard H. Griffey
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Abstract
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
Claims24
A method of inhibiting the activity, function, or amount of miR-17 (SEQ ID NO:
- 204), comprising contacting a cell with a compound comprising a modified oligonucleotide, wherein:
- the modified oligonucleotide consists of 8, 9, 10, 11, or 12 linked monomeric subunits;
- each monomeric subunit of the modified oligonucleotide comprises a modified sugar moiety;
- and
- the modified oligonucleotide is complementary to miR-17 with no more than one mismatch.
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