Gapped oligomeric compounds comprising 5′-modified deoxyribonucleosides in the gap and uses thereof

A gapped oligomeric compound comprising a contiguous sequence of linked monomer subunits having a gap region located between a 5′-region and a 3′-region wherein the 5′ and 3′-regions each, independently, have from 2 to 8 contiguous RNA-like

• modified nucleosides that each adopt a 3′-endo conformational geometry when put into an oligomeric compound and wherein the gap region has from 6 to 14 contiguous monomer subunits selected from β-D-2′-deoxyribonucleosides and 5′-substituted β-D-2′-deoxyribonucleosides having Formula I:
• wherein independently for each 5′-substituted β-D-2′-deoxyribonucleoside having Formula I:
• T1 and T2 are each, independently, an internucleoside linking group linking the 5′-substituted β-D-2′-deoxyribonucleoside having Formula I to the remainder of the gapped oligomeric compound;
• Bx is a heterocyclic base moiety;
• R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C2-C6 alkenyl, substituted C2-C6 alkenyl, C2-C6 alkynyl or substituted C2-C6 alkynyl;
• and
• wherein said gap region comprises at least one 5′-substituted β-D-2′-deoxyribonucleoside having Formula I and a plurality of β-D-2′-deoxyribonucleosides.