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US 9,752,117 B2Granted
Hybrid tissue scaffold for tissue engineering
AssigneeSouthwest Research Institute
InventorsJeffrey N. Harris, Jian Ling, Xingguo Cheng
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Abstract
A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 μm to 600 μm. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.
Claims13
A hybrid tissue scaffold comprising:
- a porous primary scaffold of biodegradable polymer having pores in a pore size range of 1.0 mm to 4.0 mm;
- a porous secondary scaffold formed from a biomaterial injectable into the pores of the porous primary scaffold, the biomaterial comprising a hydrated hydrogel including living cells, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold;
- wherein the biomaterial provides an environment to culture the living cells and the biomaterial has a pore size range of 50 μm to 600 μm;
- and
- wherein the primary scaffold provides 5% to 30% of a volume of the hybrid scaffold and said hybrid scaffold has a Young's modulus of 0.1 MPA to 100 GPa.
2 more elements
Dependencies are inferred from the claim text.