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US 9,752,115 B2Granted
Culture conditions for expansion of nephron progenitor cells
AssigneeMaine Medical Center Research Institute
InventorsLeif Oxburgh, Aaron Brown
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and methods associated with cocktails of growth factors and small molecules that target specific cell signaling pathways, the cocktails having been formulated to allow/promote the expansion of progenitor cells (e.g., nephron progenitor cells) within a defined culture system.
Claims22
A composition for expanding a mammalian progenitor cell population comprising FGF9 at 25 to 250 ng/ml, LDN-193189 at 5 to 300 nM, CHIR 99021 at 100 to 10,000 nM and at least one of BMP7 and BMP4.
Dependencies are inferred from the claim text.