Methods of reducing skeletal muscle loss using an antibody against Fn14
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorAshok Kumar
Life of this patent
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Abstract
The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system.
Claims15
A method for reducing loss of skeletal muscle in a patient, comprising administering to a patient having a battlefield injury, an accidental injury, anorexia or diabetes a therapeutically effective amount of an agent that decreases the activity of the TWEAK/Fn14 system so as to reduce the loss of skeletal muscle, wherein the agent is an Fn14 neutralizing antibody that blocks Fn14 activity.
A method for reducing loss of force production by skeletal muscle in a patient, comprising administering to a patient having a battlefield injury, an accidental injury, anorexia or diabetes a therapeutically effective amount of an agent that decreases the activity of the TWEAK/Fn14 system so as to reduce toss of force production by the skeletal muscle, wherein the agent is an Fn14 neutralizing antibody that blocks Fn14 activity.
Dependencies are inferred from the claim text.