Monoclonal antibodies against claudin-18 for treatment of cancer

An antibody that specifically binds CLD18A2, comprising:

• a heavy chain variable region (VH) having
• a VH CDR1 of positions 45-52 of SEQ ID NO:
• 118,
• a VH CDR2 of positions 70-77 of SEQ ID NO:
• 118, and
• a VH CDR3 of positions 116-126 of SEQ ID NO:
• 118;
• and
• a light chain variable region (VL) having
• a VL CDR1 of positions 47-58 of SEQ ID NO:
• 125,
• a VL CDR2 of positions 76-78 of SEQ ID NO:
• 125, and
• a VL CDR3 of positions 115-123 of SEQ ID NO:
• 125.