Antibody specific for CLEC14A and uses thereof

An antibody, binding specifically to CTLD (C-type lectin like domain) of clec14a (C-type lectin domain family 14, member A), wherein the antibody comprises at least one selected from the group consisting of:

• (a) a heavy-chain variable region comprising heavy-chain CDR1 defined by an amino acid sequence of SEQ ID NO:
• 14, heavy-chain CDR2 defined by an amino acid sequence of SEQ ID NO:
• 16, and heavy-chain CDR3 defined by an amino acid sequence of SEQ ID NO:
• 18, and a light-chain variable region comprising light-chain CDR1 defined by an amino acid sequence of SEQ ID NO:
• 42, light-chain CDR2 defined by an amino acid sequence of SEQ ID NO:
• 44, and light-chain CDR3 defined by an amino acid sequence of SEQ ID NO:
• 46;
• (b) a heavy-chain variable region comprising heavy-chain CDR1 defined by an amino acid sequence of SEQ ID NO:
• 21, heavy-chain CDR2 defined by an amino acid sequence of SEQ ID NO:
• 23, and heavy-chain CDR3 defined by an amino acid sequence of SEQ ID NO:
• 25, and a light-chain variable region comprising light-chain CDR1 defined by an amino acid sequence of SEQ ID NO:
• 49, light-chain CDR2 defined by an amino acid sequence of SEQ ID NO:
• 51, and light-chain CDR3 defined by an amino acid sequence of SEQ ID NO:
• 53;
• (c) a heavy-chain variable region comprising heavy-chain CDR1 defined by an amino acid sequence of SEQ ID NO:
• 28, heavy-chain CDR2 defined by an amino acid sequence of SEQ ID NO:
• 30, and heavy-chain CDR3 defined by an amino acid sequence of SEQ ID NO:
• 32, and a light-chain variable region comprising light-chain CDR1 defined by an amino acid sequence of SEQ ID NO:
• 56, light-chain CDR2 defined by an amino acid sequence of SEQ ID NO:
• 58, and light-chain CDR3 defined by an amino acid sequence of SEQ ID NO:
• 60;
• and
• (d) a heavy-chain variable region comprising heavy-chain CDR1 defined by an amino acid sequence of SEQ ID NO:
• 35, heavy-chain CDR2 defined by an amino acid sequence of SEQ ID NO:
• 37, and heavy-chain CDR3 defined by an amino acid sequence of SEQ ID NO:
• 39, and a light-chain variable region comprising light-chain CDR1 defined by an amino acid sequence of SEQ ID NO:
• 63, light-chain CDR2 defined by an amino acid sequence of SEQ ID NO:
• 65, and light-chain CDR3 defined by an amino acid sequence of SEQ ID NO:
• 67.