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US 9,751,924 B2Granted
Methods of using compositions comprising fusion variants of FGF19 polypeptides for reducing glucose levels in a subject
AssigneeNGM Biopharmaceuticals, Inc.
InventorsLei Ling, Darrin Anthony Lindhout
Life of this patent
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Abstract
The invention relates to methods for and uses in reducing glucose levels in subjects in need thereof with variants and fusions of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics).
Claims113
A method of reducing glucose levels in a subject in need thereof, comprising administering to the subject an effective amount of a peptide having an amino acid sequence comprising or consisting of
- (SEQ ID NO:
- 69)
- RDSSPLVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSAH
- SLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEIR
- PDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEPE
- DLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK.
3 more elements
Dependencies are inferred from the claim text.