Antimicrobial compositions comprising a hyaluronic acid binding peptide and a β-lactam antibiotic
AssigneeEmergent Biosolutions Canada Inc.
InventorsLaura Saward, Xiaobing Han, George G. Zhanel
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Abstract
Compositions and methods for the treatment of antibiotic resistant Staphylococcus aureus infections are provided comprising β-lactam antibiotics, as well as a hyaluronic acid binding peptide. The antibiotics include cephalosporins as well as the ηoη-β lactam antibiotic vancomycin. The methods provide administering the composition to the subject in an amount effective to reduce or eliminate the infection.
Claims29
A method for the prevention or treatment of antibiotic resistant S. aureus infection or reinfection, comprising administering a therapeutically effective amount of a beta-lactam antibiotic and a hyaluronic acid binding peptide comprising the amino acid sequence SEQ ID NO:
- 2.
A method of potentiating a beta-lactam antibiotic against antibiotic resistant S. aureus comprising administering a hyaluronic acid binding peptide, comprising the amino acid sequence SEQ ID NO:
- 2, with the beta-lactam antibiotic.
A composition comprising a beta-lactam antibiotic and a hyaluronic acid binding peptide comprising the amino acid sequence SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.