US 9,751,918 B2 · Transgenic plants expressing cobalamin binding proteins

Abstract

The present invention relates to the use of transgenic plants for the expression of vitamin B12 (cobalamin) binding proteins. Plant cells are transformed with nucleotide sequences adapted for expression and secretion of vitamin B12 binding proteins. The present invention also relates to the use of recombinant vitamin B12 binding proteins from plants in analytical tests and treatment of vitamin B12 deficiency. Also disclosed is a method for purification of recombinant vitamin B12 binding proteins.

Claims1

Dependent claims

A composition, the composition comprising intrinsic factor and a plant specific carbohydrate chain on the intrinsic factor, wherein all of the intrinsic factor is in the apo form.

Dependencies are inferred from the claim text.

Facts

Application

12/357,622Filed 22 Jan 2009 · continuation

Priority

GB 0117171.913 Jul 2001

Published

US 2010/0184642 A122 Jul 2010

Granted

5 Sep 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07K 14/47
From vertebrates: from mammals
A61K 31/7056
Having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides: containing five-membered rings with nitrogen as a ring hetero atom
A61K 38/168
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from plants
A61K 47/551
The modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug: one of the codrug's…

Family

PCT/GB02/03227Parent of this continuation · filed 12 Jul 2002

US 2010/0184642 A1Pre-grant publication · published 22 Jul 2010

Application10/483,849Parent of this continuation

US 2004/0268440 A1Published application

US 9,751,918 B2This patent

From the US filing history. Foreign family members aren’t listed.

Transgenic plants expressing cobalamin binding proteins

Life of this patent

Transgenic plants expressing cobalamin binding proteins

Life of this patent

Abstract

Claims1