N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)-1,3-thiazol-4-yl]amides

The compound of of Formula la

• or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer;
• wherein
• R1 is a C5-9bicycloalkyl;
• and
• R2 and R3 are each independently selected from C1-6alkyl or C3-7cycloalkyl;
• wherein the C1-6alkyl is optionally substituted with one to three fluoro or C1-3alkoxy;
• or R2 and R3 taken together with the carbon to which they are attached form a C3-6cycloalkyl ring or a 4-to 6-membered heterocycloalkyl ring, each of which is optionally and independently substituted with one to three fluoro, C1-3alkyl or C1-3alkoxy.