US 9,751,885 B2 · Cyclopropanamine compound and use thereof

Abstract

The present invention provides a compound having a lysine specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, Alzheimer's disease, Parkinson's disease or Huntington's disease, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); B is a benzene ring optionally having further substituent(s); R1, R2 and R3 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); A and R1 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s); and R2 and R3 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s), or a salt thereof.

Claims10

Dependent claims

A compound represented by the formula

wherein A is
(1) a cyclobutyl group, a cyclopentyl group, or a cyclohexyl group, each optionally having 1 or 2 fluorine atoms,
(2) a phenyl group optionally having one pyrimidinyl group, or
(3) a piperidinyl group, a pyrazolyl group, an isoxazolyl group, a thiazolyl group, a thiadiazolyl group, or a tetrahydropyranyl group, each optionally having 1 or 2 substituents selected from C1-6 alkyl groups optionally having 1 to 3 substituents selected from a fluorine atom and a cyclopropyl group;
B is a benzene ring optionally further having one substituent selected from
(1) a halogen atom,
(2) a C1-6 alkyl group, and
(3) a C1-6 alkoxy group;
R1 is a hydrogen atom;
R2 is a hydrogen atom;
and
R3 is
(1) a cyclohexyl group, a cyclopentyl group, or a cyclobutyl group, each optionally having 1 or 2 fluorine atoms,
(2) a cyclopropylmethyl group,
(3) a C1-6 alkyl group having one tetrahydropyranyl group, or
(4) a piperidinyl group or a tetrahydropyranyl group, each optionally having one substituent selected from
(a) a C1-6 alkyl group optionally having 1 to 3 fluorine atoms, and
(b) a cyclopropyl group,
or a salt thereof.

16 more elements

Dependencies are inferred from the claim text.

Cyclopropanamine compound and use thereof

Life of this patent

Cyclopropanamine compound and use thereof

Life of this patent

Abstract

Claims10