Diaryl[A, G]quinolizidine compound, preparation method therefor, pharmaceutical composition, and uses thereof

A diarylo[a,g]quinolizine compound of formula (I), an enantiomer, a diastereoisomer, a racemate, a mixture, a pharmaceutically acceptable salt, a crystalline hydrate or a solvate thereof:

• wherein
• ring A is one selected from the group consisting of benzene ring, pyrrole ring, furan ring, thiophene ring, pyridine ring, benzoxazole ring, benzofuran ring and indole ring;
• ring D is one selected from the group consisting of benzene ring, pyrrole ring, furan ring, thiophene ring, pyridine ring, benzoxazole ring and benzofuran ring;
• the rings A and D are not simultaneously benzene ring, and ring A is not an indole ring when ring D is a benzene ring;
• R5 and R10 each independently represent 1 to 4 substituents selected from the group consisting of halogen, C1-C6 straight or branched alkyl unsubstituted or substituted with 1-3 halogens, C3-C6 cycloalkyl unsubstituted or substituted with 1-3 halogens, C1-C6 straight or branched alkyl substituted with a C 1-C6 alkoxy, C1-C6 straight or branched alkyl substituted with a C3-C6 cycloalkyl, —OR6, —NR6R7, —OR9OR6, —OR9NR6R7, —R9COOR6, —R9CONR6R7, —R9OR6, —R9NR6R7, and —N(R6)SO2R7,
• alternatively, any two adjacent R5s or adjacent R10s, together with the carbon atom or the heteroatom to which they are adjacent, may form a 5-7 membered heterocycle containing 1 to 3 heteroatoms selected from the group consisting of N, O and S;
• R1, R2and R3 are each independently hydrogen, halogen, hydroxy, oxo (═O), or C1-C6 straight or branched alkyl unsubstituted or substituted with 1-3 halogens,
• R4 is hydrogen, halogen, hydroxy, or C1-C6 straight or branched alkyl unsubstituted or substituted with 1-3 halogens,
• R6 and R7 are each independently hydrogen, or C1-C6 straight or branched alkyl unsubstituted or substituted with 1-3 halogens or hydroxys,
• R9 is C1-C6 straight or branched alkylene;
• the halogen is F, Cl or Br;
• and
• the chiral carbon atom in the compound of formula (I) may be on R- or S- configuration.