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US 9,751,878 B2Granted
Tetrahydronaphthyridine somatostatin receptor 5 antagonists
AssigneeTakeda Pharmaceutical Company Limited
InventorsShizuo Kasai, Hideki Hirose, Takeshi Yamasaki, Tohru Yamashita, Asato Kina, Yoichi Nishikawa
Life of this patent
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Abstract
A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.
Claims9
A compound represented by the following formula:
- wherein
- ring P is pyridine;
- W is methylene;
- ring A is piperidine, azetidine, or pyrrolidine;
- ring B is
- (1) a benzene ring optionally substituted by 1 to 4 substituents selected from:
- a halogen atom;
- a C3-10 cycloalkyl group;
- a C1-6 alkoxy group;
- and a C6-14 aryl group optionally substituted by 1 to 3 halogen atom(s), or
- (2) pyridine optionally substituted by 1 to 3 substituents selected from:
- a C1-6 alkyl group;
- a C3-10 cycloalkyl group;
- a C1-6 alkoxy group and a C6-14 aryl group optionally substituted by 1 to 3 halogen atom(s);
- R1 is COOH and R2 is a hydrogen atom, a C1-6 alkyl group optionally substituted by a C1-6 alkoxy group, a C3-10 cycloalkyl group, or COOH;
- or
- R1 is a hydrogen atom and R2 is COOH;
- and
- each of R3, R4, R5, and R6 is a hydrogen atom.
16 more elements
A compound represented by the following formula:
- wherein
- ring P constitutes 1,6-tetrahydronaphthyridine together with the adjacent ring;
- ring A is piperidine;
- ring B is a benzene ring optionally substituted by 1 to 4 substituents selected from:
- a halogen atom, a C3-10 cycloalkyl group, a C1-6 alkoxy group, and a C6-14 aryl group optionally substituted by 1 to 3 halogen atom(s);
- and
- R1 is COOH and R2 is a hydrogen atom, a C1-6 alkyl group optionally substituted by a C1-6 alkoxy group, a C3-10 cycloalkyl group;
- or COOH;
- or
- R1 is hydrogen atom and R2 is COOH;
- or a salt thereof.
8 more elements
Dependencies are inferred from the claim text.