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AssigneeHoffman-La Roche Inc.
InventorsCaterina Bissantz, Christophe Grundschober, Matthias Nettekoven, Jean-Marc Plancher, Walter Vifian
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The invention relates to the use of a compound of formula I wherein A1 is phenyl or a five or six membered hereroaryl group, containing 1, 2 or 3 heteroatoms, selected from N or S; R1 is hydrogen, lower alkyl, halogen, lower alkyl substituted by halogen or cycloalkyl; A2 is phenyl; R2 is halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cyano, S-lower alkyl substituted by halogen, S(O)2-lower alkyl substituted by halogen; n is 1 or 2; or a pharmaceutically acceptable acid addition salt, or a racemic mixture or its corresponding enantiomer and/or optical isomers thereof, for the treatment of autism, stress, including post traumatic stress disorder, anxiety, including anxiety disorders and depression, schizophrenia, psychiatric disorders and memory loss, alcohol withdrawal, drug addiction and for the treatment of Prader-Willi Syndrome.
A method of treating a condition selected from the group consisting of autism, stress, post traumatic stress disorder, anxiety disorders, depression, schizophrenia, psychiatric disorders, memory loss, alcohol withdrawal, drug addiction and Prader-Willi Syndrome, comprising administering a compound of formula I
A method of treating a condition selected from the group consisting of autism, stress, post traumatic stress disorder, anxiety disorders, depression, schizophrenia, psychiatric disorders, memory loss, alcohol withdrawal, drug addiction and Prader-Willi Syndrome, comprising administering a compound selected from the group consisting of
A pharmaceutical composition comprising a compound selected from the group consisting of
A compound selected from the group consisting of
A compound of formula IA,
A compound selected from the group consisting of
A process for preparation of a compound of formula IA, or a pharmaceutically acceptable acid addition salt, a racemic mixture or its corresponding enantiomer and/or optical isomers thereof, which process comprises
Dependencies are inferred from the claim text.