N1-(3,3,3-trifluoro-2-hydroxo-2-methylpropionyl)-piperidine derivatives as inhibitors of pyruvate dehydrogenase kinase

A compound,

• wherein the compound is a compound of formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof,
• wherein formula (I) is
• wherein
• R denotes pyrazol-diyl, imidazol-diyl, isoxazol-diyl or triazol-diyl, each of which is unsubstituted or monosubstituted by R2,
• R1 denotes (CH2)nAr, (CH2)nHet, A or Cyc,
• R2 denotes A′, methoxy, hydroxy methyl, COOA′, CN, COOH, CONH2 or OH,
• R3 denotes H, A′, COOA′ or CN,
• Ar denotes phenyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, CN, OA, [C(R5)2]pOH, [C(R5)2]pN(R5)2, NO2, [C(R5)2]pCOOR5, NR5COA, NR5SO2A, [C(R5)2]pSO2N(R5)2, S(O)nA, O[C(R5)2]mN(R5)2, NR5COOA, NR5CON(R5)2 and/or COA,
• Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono- or disubstituted by Hal, A, CN, OA, [C(R5)2]pOH, [C(R5)2]pN(R5)2, NO2, [C(R5)2]pCOOR5, NR5COA, NR5SO2A, [C(R5)2]pSO2N(R5)2, S(O)nA, O[C(R5)2]mN(R5)2, NR5COOA, NR5CON(R5)2 and/or COA,
• Cyc denotes cyclic alkyl with 3, 4, 5, 6 or 7 C-atoms, which is unsubstituted or monosubstituted by OH,
• A denotes unbranched or branched alkyl with 1-10 C-atoms, wherein one or two non-adjacent CH— and/or CH2-groups are optionally replaced by N—, O— and/or S-atoms and/or wherein 1-7 H-atoms are optionally replaced by R4,
• R4 denotes F, Cl or OH,
• R5 denotes H or A′,
• A′ denotes unbranched or branched alkyl with 1-6 C-atoms, wherein 1-5H-atoms are optionally replaced by F,
• Hal denotes F, Cl, Br or I,
• m denotes 1, 2, 3 or 4,
• n denotes 0, 1 or 2, and
• p denotes 0, 1, 2, 3 or 4.