Back to results
US 9,751,856 B2Granted
Ethynyl derivatives
AssigneeHoffmann-La Roche Inc.
InventorsGeorg Jaeschke, Lothar Lindemann, Rainer E. Martin, Antonio Ricci, Daniel Rueher, Heinz Stadler, Eric Vieira
Life of this patent
Estimating the term…
Abstract
The present invention relates to ethynyl derivatives as metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of, e.g., anxiety and pain, depression, Fragile-X syndrome, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).
Claims3
A compound of formula I
- wherein
- Y is N;
- R1 is hydrogen, fluoro or chloro;
- and
- R2 is hydrogen or lower alkyl;
- or a pharmaceutically acceptable acid addition salt thereof.
3 more elements
Dependencies are inferred from the claim text.