Methods and compositions related to neuroactive thiazoline compounds

A method for treating a disorder in a mammal, the method comprising the step of administering to the mammal an effective amount of least one compound having a structure represented by a formula:

• wherein ----- is an optional covalent bond, wherein valency is satisfied;
• wherein Z is selected from O and S;
• wherein R1 is selected from hydrogen and optionally substituted C1-C6 alkyl;
• wherein R2 is selected from nitrile, formyl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted alkoxyl, optionally substituted thioalkyl, optionally substituted alkylsulfonyl, thioamido, amino-carbonyl, and alkylamine-carbonyl;
• wherein R3 is selected from hydrogen and optionally substituted C1-C6 alkyl;
• wherein each of R4a, R4b,R4c, and R4d is independently selected from hydrogen, halogen, hydroxyl, nitrile, nitro, thiol, formyl, optionally substituted amino, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxyl, optionally substituted thioalkyl, optionally substituted alkylsulfinyl, optionally substituted alkyl sulfonyl, optionally substituted alkylamino, thioamido, amidosulfonyl, alkoxycarbonyl, carboxamide, amino-carbonyl, alkylamine-carbonyl, and optionally substituted C1-C6 alkyl;
• or a pharmaceutically acceptable salt thereof,
• wherein the disorder is asthma.