Antimicrobial biguanide metal complexes
AssigneeSmith & Nephew, Inc.
InventorBryan Greener
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Abstract
A compound comprising a metal species and a biologically acceptable ligand, wherein the biologically acceptable ligand comprises a biguanide moiety, and wherein the biologically acceptable ligand forms a complex with the metal species in which the metal species is stabilised in an oxidation state greater than 1+. Compositions and medical devices comprising the compound. A method for the treatment or prophylaxis of microbial, including bacterial, infections, comprising the use of such compounds, compositions or medical devices.
Claims7
A method for the treatment of microbial infections, comprising administering to an individual a compound comprising a metal species and a biologically acceptable ligand, wherein the metal species is selected from the group consisting of silver (III), copper (III), and gold (III);
- wherein the biologically acceptable ligand comprises a biguanide moiety;
- wherein the biologically acceptable ligand forms a complex with the metal species in which the metal species is stabilized in an oxidation state greater than 1+;
- and wherein the step of administering to an individual comprises contacting the individual with the compound.
Dependencies are inferred from the claim text.