US 9,751,758 B2 · Rational assembly of nanoparticle superlattices with designed lattice symmetries

Abstract

A method for lattice design via multivalent linkers (LDML) is disclosed that introduces a rationally designed symmetry of connections between particles in order to achieve control over the morphology of their assembly. The method affords the inclusion of different programmable interactions within one linker that allow an assembly of different types of particles. The designed symmetry of connections is preferably provided utilizing DNA encoding. The linkers may include fabricated “patchy” particles, DNA scaffold constructs and Y-shaped DNA linkers, anisotropic particles, which are preferably functionalized with DNA, multimeric protein-DNA complexes, and particles with finite numbers of DNA linkers.

Claims16

Dependent claims

A controllable nanoparticle superlattice comprising,

a linker comprising a specified symmetry of connecting sites, wherein the linker is a symmetric DNA scaffold construct, an anisotropic particle, a multimeric protein-DNA complex, or a “patchy” particle, and wherein the connecting sites of the linker have non-complementary DNA and/or RNA attached thereto;
and
a nanoparticle encapsulated with non-complementary DNA and/or RNA, wherein the non-complementary DNA and/or RNA of the nano particle is complementary to the non-complementary DNA and/or RNA of the linker so as to form a nanoparticle superlattice, wherein the symmetry of the superlattice is determined by the specified symmetry of the connecting sites of the linker.

Dependencies are inferred from the claim text.

Facts

Application

14/373,161Filed 18 Jan 2013 · us provisional application

Priority

18 Jan 2012

Published

US 2015/0017444 A115 Jan 2015

Granted

5 Sep 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

B82B 3/00
Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules
C12Q 1/68
Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such…
B82Y 30/00
Nanotechnology for materials or surface science
B82Y 40/00
Manufacture or treatment of nanostructures

Rational assembly of nanoparticle superlattices with designed lattice symmetries

Life of this patent

Rational assembly of nanoparticle superlattices with designed lattice symmetries

Life of this patent

Abstract

Claims16