Facility wide mixed mail sorting and/or sequencing system and components and methods thereof

A system, comprising:

• a plurality of frames transported in a face-to-face orientation;
• at least one frame inserter which is structured to place individual mail pieces into each of the plurality of frames;
• a plurality of shuttles which are structured to store the plurality of frames in the face-to-face orientation;
• a receiving and/or discharge station which is structured and arranged to receive and discharge the shuttles;
• and
• a transportation system adjacent to a plurality of storage aisles and cells, the transportation system comprising a plurality of platforms which are moveable through multiple levels of storage comprising the storage aisles and storage cells and which are structured and arranged to transport the shuttles through each level of the multiple levels.