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US 9,750,954 B2Granted
Concurrent delivery of interstitial thermobrachytherapy (hyperthermia and brachytherapy) in the treatment of cancer
AssigneeThe University of Toledo
InventorsE. Ishmael Parsai, Diana Shvydka, Gregory Warrell
Life of this patent
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Abstract
A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic, ferromagnetic, or ferrimagnetic properties.
Claims26
A brachytherapy seed comprising:
- a seed having within an interior space thereof a core comprising a ferromagnetic material;
- an electroplated conductive layer sheath on the surface of the core;
- and
- at least one layer comprising a radiation emission material that surrounds the core, wherein the radiation emission material comprises one or more of I-125, Pd-103, or Cs-131 radionuclides;
- and
- a metal shell surrounding the at least one layer comprising the radiation emission material;
- wherein no void exists between the core and the radiation emission material that surrounds the core.
4 more elements
A system, comprising:
- one or more implantable medical seeds, each implantable medical seed of the one or more implantable medical seeds including a body having an interior space and having at least one outer surface;
- one or more ferromagnetic energy-emitting elements comprising a ferromagnetic material positioned within the interior space of each said implantable medical seed, the one or more ferromagnetic energy-emitting elements configured to at least intermittently deliver a therapeutic dose of heat to tissue proximate to the at least one outer surface of each said implantable medical seed;
- and
- one or more radiation-emitting elements positioned within the interior space of each of the implantable medical seeds, the one or more radiation-emitting elements forming at least one layer that completely surrounds the one or more ferromagnetic energy-emitting elements positioned within the interior space of each said implantable medical seed, the one or more radiation-emitting elements configured to deliver a therapeutic dose of radiation to tissue proximate to the at least one outer surface of each said implantable medical seed;
- wherein the system is adapted to include a controller configured to apply an electro-magnetic or magnetic field to the one or more implantable medical seeds;
- and
- wherein no void exists between the ferromagnetic energy-emitting elements of each said implantable medical seed and the one or more radiation-emitting elements that surround the ferromagnetic energy-emitting elements.
4 more elements
Dependencies are inferred from the claim text.