Criteria for determination of local tissue latency near pacing lead electrodes

An apparatus for adjusting one or more control pacing parameters for cardiac resynchronization, comprising:

• (a) delivering means for delivering biventricular pacing stimulus comprising a right ventricular pacing stimulus and a left ventricular pacing stimulus simultaneously at a short atrioventricular (AV) delay equal to or less than 60 ms;
• (b) sensing means for sensing a signal in response to the biventricular pacing stimulus;
• (c) processing means for determining from the signal a maximum amplitude (Max), a maximum time (Tmax) associated with the Max, a minimum amplitude (Min), and a minimum time (Tmin) associated with the Min, determined within pre-specified time period following the delivery of the biventricular pacing;
• (d) processing means for determining whether Tmin>Tmax associated with the signal;
• and
• (e) processing means for determining whether to adjust VV delay in response to determining Tmin>Tmax.

A medical device system or determining presence of local tissue latency, the system comprising:

• an implanted lead having a first electrode for cardiac pacing and sensing;
• a sensing module for producing a waveform in response to delivering a pacing stimulus;
• a processor configured to:
• (a) setting one or more pacing control parameters including setting an atrioventricular (AV) delay to less than or equal to 60 ms,
• (b) extracting two or more features from the waveform, wherein the two or more features comprise at least a minimum time (Tmin) associated with a minimum amplitude of the waveform,
• (c) identifying whether local tissue latency is at a site of the first electrode based upon the at least two of the extracted features indicating local tissue latency, and
• (d) in response to identifying local tissue latency, adjusting the one or more pacing control parameters.

An apparatus for adjusting pacing parameters for cardiac resynchronization, comprising

• a) delivering a left ventricular pacing stimulus at a short AV delay equal to or less than 60 ms;
• b) sensing a signal in response to the left ventricular stimulus and determining if the time-interval between the timing (Tmin) of the minimum amplitude and the time of delivery of the stimulus is 100 ms or greater, where the minimum amplitude is determined within a pre-specified time-period following the delivery of the pacing stimulus;
• c) delivering a right ventricular pacing stimulus and a left ventricular pacing stimulus simultaneously at a short AV delay equal to or less than 60 ms;
• d) sensing a signal in response to the biventricular pacing stimulus and determining if timing (Tmax) of max amplitude precedes timing (Tmin) of the minimum amplitude where both maximum and minimum amplitudes are determined within a pre-specified time-period following delivery of the pacing stimuli;
• and
• e) adjusting pacing parameters in response to determining if Train for the left ventricular stimulus is 100 ms or greater than 100 ms, or if Tmax precedes Tmin for the biventricular pacing stimulus.

A non-transitory, computer-readable storage medium comprising instructions that, when executed, cause a processor included in a medical device system to:

• (a) deliver a left ventricular pacing stimulus at a short atrioventricular (AV) delay equal to or less than 60 ms;
• (b) sense a signal in response to the ventricular pacing stimulus;
• (c) determine from the signal a minimum time (Tmin) associated with the minimum amplitude;
• (d) determine whether Tmin≧100 milliseconds (ms);
• and
• (e) determine whether to adjust control pacing parameters, in response to determining whether Tmin≧100 ms, wherein the control pacing parameters being one of AV delay, inter-ventricular (VV) delay, pacing vector, and pacing output.

A medical device system for determining presence of local tissue latency, the system comprising:

• an implanted lead having a first electrode for cardiac pacing and sensing;
• a sensing module for sensing heart activity with the first electrode to produce a electrogram (EGM) waveform;
• and
• a processor configured to:
• acquire or access the EGM waveform and extract two or more features from the EGM waveform representative of heart activity at the electrode, wherein the two or more features comprise at least a minimum time (Tmin) associated with a minimum amplitude of the EGM waveform, and
• identify local tissue latency at a site of the first electrode based upon the at least two of the extracted features indicating local tissue latency.