Method of preparing an implantable neuroendoprosthetic system

A method of production of an implantable neuroendoprosthetic system for transubstantiation of defects of brain, spinal cord and vegetative nervous system in a mammal in reconstructive neurosurgical operations, comprising the steps of:

• providing a heterogeneous collagen-containing matrix for implantation,
• providing a cell preparation of autologous cells of a patient, and
• perfusing said preparation into said matrix to thereby obtain an elastic cell-biopolymer biologically active mass,
• wherein the cell preparation comprises placed in a NaCl solution at least one type of cells from a group comprising neural stem cells (NSC), neuroglial ensheathing cells (NGEC), endothelial cells with CD34+ marker (EC), and purified mononuclears (MN), said cells are in the following ratios (in parts according to numbers of the cells) in the cell preparation:
• 0.8 to 1.2 of NSC;
• 1.6 to 2.4 of NGEC;
• 4 to 6 of EC;
• 4000 to 6000 of MN.