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OwnerPaul B. Fisher, Swadesh K. Das +4inventors
InventorsPaul B. Fisher, Swadesh K. Das, Rupesh Dash, Devanand Sarkar, Siddik Sarkar, Jolene Windle
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Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1 cancer selective promoter (tCCN1-Prom) are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, and the transgenic mice are used to monitor cancer progression, e.g. in screening assays.
A recombinant vector comprising a truncated connective tissue growth factor/cysteine rich protein/nephroblastoma overexpressed gene-1 (CCN1) cancer selective promoter comprising the nucleotide sequence as set forth in SEQ ID NO:
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