IgG Fc fragment for a drug carrier and method for the preparation thereof
AssigneeHanmi Science Co., Ltd.
InventorsSung Youb Jung, Jin Sun Kim, Geun Hee Yang, Se Chang Kwon, Gwan Sun Lee
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Abstract
Disclosed is an IgG Fc fragment useful as a drug carrier. A recombinant vector expressing the IgG Fc fragment, a transformant transformed with the recombinant vector, and a method of preparing an IgG Fc fragment are disclosed. When conjugated to a certain drug, the IgG Fc fragment improves the in vivo duration of action of the drug and minimizes the in vivo activity reduction of the drug.
Claims4
An IgG Fc fragment as a drug carrier, wherein the IgG Fc fragment is covalently linked to a drug through a non-peptide linker, wherein the non-peptide linker is a polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, polyoxyethylated polyols, polyvinyl alcohol, dextran, polyvinyl ether, polylactic acid, polylactic-glycolic acid, a lipid polymer, a chitin, or hyaluronic acid, and wherein the IgG Fc fragment is aglycosylated and consists of the amino acid sequence of SEQ ID NO:
- 23.
An IgG Fc fragment as a drug carrier, the IgG Fc fragment being covalently linked to a drug through a non-peptide linker, wherein the non-peptide linker is a polyethylene glycol having a molecular weight of 3.4 kDa or 10 kDa, wherein the IgG Fc fragment is aglycosylated and consists of the amino acid sequence of SEQ ID NO:
- 23.
Dependencies are inferred from the claim text.