Vaccine preparation containing trifunctional antibodies with antigen immunogenicity enhancer properties
AssigneeTRION Research Gmbh
InventorHorst Lindhofer
Life of this patent
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Abstract
The present invention refers to a pharmaceutical composition containing trifunctional bispecific and/or trispecific antibodies being capable of binding to a specific target antigen(s) for use in a method of immunizing mammals against diseases in which said target antigen(s) is (are) involved, and further to a pharmaceutical composition containing trifunctional bispecific and/or trispecific antibodies being capable of binding to (a) specific target antigen (s) which is (are) involved in a disease of a mammal, specifically a human.
Claims23
A pharmaceutical composition comprising:
- 1) a trifunctional bispecific antibody and/or a trispecific antibody having the following properties:
- (a) binding to a T cell via CD3 and activating said T cell;
- (b) binding to a target antigen other than CD3;
- (c) binding to Fcγ-receptor type I, II and/or III positive cells via an Fc-portion, or by a third antigen specificity;
- and
- 2) a pharmaceutically acceptable carrier selected from the group consisting of homologous virus-like particles (VLP) and heterologous/chimeric VLP, wherein said target antigen and optionally one or more further antigens are associated with or conjugated to the VLP.
A kit comprising two containers, the first container containing a trifunctional bispecific and/or trispecific antibody having the following properties:
- (a) binding to a T cell via CD3 and activating said T cell;
- (b) binding to a target antigen other than CD3;
- (c) binding to Fcγ-receptor type I, II and/or III positive cells via an Fc-portion, or by a third antigen specificity;
- and
- a second container containing a carrier selected from the group consisting of homologous virus-like particles (VLP) and heterologous/chimeric VLP, wherein said target antigen and optionally one or more further antigens are conjugated to or associated with the VLP.
Dependencies are inferred from the claim text.