Calcium flux agonists and methods therefor
AssigneeNant Holdings IP, LLC
InventorsKayvan Niazi, Shahrooz Rabizadeh, Justin Golovato, Patrick Soon-Shiong, Anne-Laure Le Ny, Oleksandr Buzko
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Abstract
Calcium flux agonists are used to enhance a TLR- or NOD-mediated stimulus and to so increase an immune response of a host and reduce healing time. Preferred calcium flux agonists include Ca2+ ionophores and SERCA inhibitors and are used in synergistic quantities where a ligand to a TLR or NOD receptor is present.
Claims20
A method of enhancing an immune response of an immune competent cell to a ligand of a pattern recognition receptor, comprising a step of contacting the immune competent cell with a calcium flux agonist at a concentration effective to enhance the immune response.
A method of enhancing an immune response of an immune competent cell to a ligand of a pattern recognition receptor, comprising:
- contacting the immune competent cell with a calcium flux agonist at a concentration effective to enhance the immune response;
- wherein the immune response is an increased IL-8 secretion or an increased activation of NF-κB signaling;
- and
- wherein the pattern recognition receptor is a TLR receptor or a NOD receptor.
Dependencies are inferred from the claim text.