US 9,750,795 B2 · Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections

Abstract

Nucleic acid molecules which encode an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are disclosed. Novel proteins which comprise a MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed are disclosed. Methods of inducing an immune response against MRSA PBP2a are disclosed, as are methods of treating an individual who has been diagnosed with MRSA and methods of preventing MRSA infection in an individual.

Claims18

Dependent claims

A nucleic acid molecule that encodes a Methicillin-resistant Staphylococcus aureus (MRSA) penicillin-binding protein 2a (PBP2a) protein or a fragment thereof which comprises at least 245 amino acid, the nucleic acid molecule comprising:

an optimized nucleic acid sequence that is at least 98% identical to SEQ ID NO:1 and that encodes a consensus protein at least 98% identical to SEQ ID NO:2;
or
an optimized nucleic acid sequence that is at least 98% identical to a fragment of SEQ ID NO:1 and that encodes a fragment of a consensus protein at least 98% identical to SEQ ID NO:2, wherein the fragment encodes an immunogenic fragment of a protein that is 98% identical to a fragment of SEQ ID NO:2 comprising at least 245 amino acids.

Dependencies are inferred from the claim text.

Facts

Application

14/365,071Filed 11 Dec 2012 · us provisional application

Priority

12 Dec 2011

Published

US 2014/0341944 A120 Nov 2014

Granted

5 Sep 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 39/085
Bacterial antigens: staphylococcus
A61K 38/20
Cytokines; Lymphokines; Interferons: interleukins [IL]
A61K 38/208
Interleukins [IL]: il-12
A61K 38/2086
Interleukins [IL]: il-13 to il-16

Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections

Life of this patent

Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections

Life of this patent

Abstract

Claims18