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US 9,750,788 B2Granted
Non-acylated exendin-4 peptide analogues
AssigneeSanofi
InventorsDieter Kadereit, Katrin Lorenz, Andreas Evers, Torsten Haack, Michael Wagner, Bernd Henkel, Martin Lorenz, Siegfried Stengelin
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Abstract
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
Claims23
A peptidic compound having the formula (I):
- (I)
- R1-Z-R2,
- or a salt or solvate thereof,
- wherein Z is a peptide moiety having the formula (II):
- (II)
- Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-X12-
- Leu-Leu-X15-X16-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-
- Trp-Leu-Lys-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-
- Pro-Pro-Ser,
- wherein:
- X12 is an amino acid residue selected from Lys and Ile,
- X15 is an amino acid residue selected from Glu and Asp,
- X16 is an amino acid residue selected from Glu and Lys,
- R1 is —NH2, and
- R2 is —OH or —NH2.
12 more elements
Dependencies are inferred from the claim text.