Intraarticular application of pepstatin in the case of arthrosis
AssigneeMerck Patent GmbH
InventorsMarkus Klein, Ralf Wodopia, Hans Guehring, Sven Lindemann
Life of this patent
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Abstract
The present invention relates to pharmaceutical preparations and medicaments for intraarticular administration, comprising pepstatin, and to the preparation and use thereof, in particular in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia, particularly preferably in arthrosis.
Claims12
A method for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, selected from the group consisting of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia and hyperalgesia, comprising intraarticular administration to a patient in need of said treatment of a pharmaceutical preparation
- comprising pepstatin and/or one of its physiologically acceptable salts, solvates, prodrugs and stereoisomers, including mixtures thereof in all ratios, and one or more excipients and/or adjuvants, said preparation formulated for intraarticular administration for the treatment and/or prophylaxis of said physiological and/or pathophysiological conditions,
- wherein the pharmaceutical preparation is formulated for administration weekly to yearly, and
- wherein the pharmaceutical preparation is administered weekly to yearly.
A method for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, selected from the group consisting of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia and hyperalgesia, comprising intraarticularly administering to a patient in need thereof pepstatin and/or one of its physiologically acceptable salts, solvates, prodrugs and stereoisomers, including mixtures thereof in all ratios,
- wherein the pepstatin and/or one of its physiologically acceptable salts, solvates, prodrugs and stereoisomers is administered weekly to yearly.
A method for the treatment and/or prophylaxis of arthrosis, comprising intraarticularly administering to a patient in need thereof pepstatin and/or one of its physiologically acceptable salts, solvates, prodrugs and stereoisomers, including mixtures thereof in all ratios,
- wherein the pepstatin and/or one of its physiologically acceptable salts, solvates, prodrugs and stereoisomers, including mixtures thereof in all ratios, is administered weekly to yearly.
Dependencies are inferred from the claim text.