Reactive oxidative species generating materials and methods of use
AssigneeW. L. Gore & Associates, Inc.
InventorsTiffany J. Brown, Adam S. Lafleur, Kenneth Mazich, Jeffrey C. Towler, Ji Zhang
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Abstract
Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.
Claims27
A biocompatible device capable of releasing superoxide, said biocompatible device comprising:
- a substrate;
- and
- a biocompatible material comprising a first semi-crystalline, hydrolytically degradable polymeric material and a second semi-crystalline hydrolytically degradable polymeric material,
- wherein the first and second polymeric materials have each been subjected to ionizing radiation at a dose rate less than about 50 kGy and sterilized by non-ionizing radiation methods,
- wherein said biocompatible material is in contact with at least a portion of said substrate,
- wherein an initial burst of reactive oxidative species production and a subsequent sustained period of reactive oxidative species production occurs upon contacting the biocompatible material with an oxygen-containing aqueous media, and
- wherein the first polymeric material and the second polymeric material have been subjected to different doses of ionizing radiation.
A biocompatible device capable of releasing superoxide, said biocompatible device comprising:
- a substrate;
- and
- a biocompatible material comprising a first semi-crystalline, hydrolytically degradable polymeric material and a second semi-crystalline hydrolytically degradable polymeric material,
- wherein the first polymeric material and second polymeric material have been subjected to different doses of ionizing radiation while maintained in an inert atmosphere,
- wherein said biocompatible material is in contact with at least a portion of said substrate.
Dependencies are inferred from the claim text.