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US 9,750,763 B2Granted
Solution for peritoneal dialysis
AssigneeFresenius Medical Care Deutschland GmbH
InventorThomas Zimmeck
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AssigneeFresenius Medical Care Deutschland GmbH
InventorThomas Zimmeck
Estimating the term…
The present invention relates to a solution for peritoneal dialysis, consisting of at least two single solutions which are combined after a heat sterilization and are administered to a patient, the first single solution containing an osmotic and the second single solution containing a buffer, and one of these single solutions or another single solution containing electrolyte salts. The avoidance of a glucose-like degradation as well as hydrolysis during sterilization and storage while maintaining a neutral mixture pH is achieved according to the invention by the osmotic comprising a glucose polymer and/or glucose polymer derivative, and the pH of the first single solution being between 3.5 and 5.0. The present invention further relates to a twin-chambered pouch consisting of a plastic pouch with at least one first chamber and a second chamber, the first single solution being included in the first chamber and the second single solution being included in the second chamber.
A multi-part solution, for peritoneal dialysis designed to be mixed prior to infusion, comprising at least a first single solution and a second single solution, the first single solution containing an osmotic, sodium ions, and chloride ions, and the second single solution containing a buffer and not containing the osmotic, wherein (1) the osmotic comprises at least one of a glucose polymer and a glucose polymer derivative, (2) the first single solution has a pH in the range between 4.0 and 5.0, (3) the buffer contains lactate, (4) bicarbonate ions and calcium ions are not present together in any solution prior to mixing, and (5) lactate and glucose polymer or lactate and glucose polymer derivative are not present together in any solution prior to mixing.
A multi-part solution for peritoneal dialysis designed to be mixed prior to infusion, comprising at least a first single solution and a second single solution, the first single solution containing an osmotic and the second single solution containing a buffer and not containing the osmotic, and one of the first single solution, the second single solution, and a third single solution containing electrolyte salts,
A multi-part solution for peritoneal dialysis designed to be mixed prior to infusion, comprising at least a first and a second single solution, the first single solution containing an osmotic and hydrochloric acid, and the second single solution containing a buffer and not containing the osmotic, and one of the first single solution, the second single solution, and a third single solution containing electrolyte salts,
Dependencies are inferred from the claim text.