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US 9,750,757 B2Granted
Methods of prevention or treatment for pathologic thrombosis or inflammation
AssigneeThomas Jefferson University
InventorsPaul F. Bray, Michael Holinstat
Life of this patent
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Abstract
The present disclosure relates to methods of affecting platelet activation by the use of a PC-TP inhibitor. The PC-TP inhibitor can be administered to a subject in need thereof in order to prevent or treat pathologic thrombosis, or to treat a disorder treatable by a PAR4 inhibitor.
Claims6
A method of inhibiting platelet activation, the method comprising contacting a platelet with a PC-TP inhibitor 2,4-dichloro-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenylcarbamoyl)-benzamide (LDN-193,188), or a pharmaceutically acceptable salt thereof, and wherein the PC-TP inhibitor inhibits PAR4 activation.
Dependencies are inferred from the claim text.