Celecoxib compositions
AssigneePfizer Inc.
InventorsDanchen Gao, Anthony J. Hlinak, Ahmad M. Mazhary, James E. Truelove, Margaret B. Vaughn
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Abstract
Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising particulate celecoxib in an amount of about 10 mg to about 1000 mg in intimate mixture with one or more pharmaceutically acceptable excipients. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders.
Claims7
A pharmaceutical composition comprising one or more orally deliverable dose units, each comprising particulate celecoxib in an amount of about 10 mg to about 1000 mg in intimate mixture with one or more pharmaceutically acceptable excipients, and having a distribution of celecoxib particle sizes such that D90 of the particles is less than 200 um;
- said composition exhibiting upon oral administration a relative bioavailability not less than about 50% by comparison with an orally delivered solution containing celecoxib at the same dosage rate, wherein said excipients include:
- a. one or more pharmaceutically acceptable diluents in a total amount of about 5% to about 99% by weight of the composition;
- b. one or more pharmaceutically acceptable disintegrants in a total amount of about 0.2% to about 30% by weight of the composition;
- c. one or more pharmaceutically acceptable binding agents in a total amount of about 0.5% to about 25% by weight of the composition;
- d. one or more pharmaceutically acceptable wetting agents in a total amount of about 0.25% to about 15% by weight of the composition;
- and
- e. one or more pharmaceutically acceptable lubricants in a total amount of about 0.1% to about 10% by weight of the composition.
Dependencies are inferred from the claim text.