Back to results
US 9,750,748 B2Granted
Pyridazinones as DAAO enzyme inhibitors
AssigneeTakeda Pharmaceutical Company Limited
InventorsWilliam Farnaby, Charlotte Fieldhouse, Katherine Hazel, Catrina Kerr, Natasha Kinsella, David Livermore, Kevin Merchant, David Miller
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
Claims18
A compound of formula (I), or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is chosen from a hydrogen or fluorine atom or a trifluoromethyl group;
- R2 is chosen from a C2-C8 alkyl, C3-C8 cycloalkyl, tetrahydropyranyl, or —NR3R4 group,
- wherein the alkyl, cycloalkyl and tetrahydropyranyl groups are unsubstituted or substituted by at least one substituent chosen from halogen, hydroxyl, cyano, carboxyl, C1-C6 alkyl, difluoromethyl, trifluoromethyl, C1-C6 alkoxy, difluoromethoxy or trifluoromethoxy;
- R3 and R4 are each independently chosen from a hydrogen atom or a C1-C6 alkyl group, or R3 and R4 together with the nitrogen atom to which they are attached form a saturated or unsaturated 4- to 8-membered heterocyclic ring, wherein each alkyl group or the heterocyclic ring is unsubstituted or substituted by at least one substituent chosen from halogen, hydroxyl, cyano, carboxyl, C1-C6 alkyl, difluoromethyl, trifluoromethyl, C1-C6 alkoxy, difluoromethoxy or trifluoromethoxy;
- with the proviso that the compound of formula (I) is not:
- 2,3 -dihydro-4-hydroxy-6-morpholinopyridazin-3 -one, or
- 6-amino-4-hydroxy-pyridazinone.
5 more elements
Dependencies are inferred from the claim text.