Small molecular inhibitors of RAD51 recombinase and methods thereof

A method of treating a RAD51-overexpressing cancer in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a pharmaceutically effective amount of at least one compound selected from the group consisting of Formula (1), Formula (2), Formula (3), a salt thereof, and any combinations thereof:

• wherein in (1):
• R1 is pyridinyl,
• R2 is selected from the group consisting of C1-C6 alkyl, —(C1-C6)alkylene-phenyl, and —(C1-C6)alkylene-phenyl wherein the phenyl is substituted with a C1-C6 alkyl;
• and
• R3 is H;
• the method further comprising administering to the subject a treatment selected from the group consisting of (i) radiation therapy, and (ii) a pharmaceutically effective amount of a chemotherapeutic agent.