Back to results
US 9,750,728 B2Granted
Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway
AssigneeTargeted Therapeutics, LLC
InventorsLei Duan, Victor Levenson, GuoGuang Ying
Life of this patent
Estimating the term…
Abstract
A method of treating a patient in need of treatment for a disease selected from the group consisting of cancer, hamartoma syndrome and hereditary myopathy, the method comprising administering to the patient an effective dose of at least one PRCP and PREP dual antagonist pyridine compound of Formula (I) or an acid salt thereof, which can be administered either alone or in combination with at least one mTOR inhibitor.
Claims9
A method of treating cancer, the method comprising administering to a patient in need thereof an effective dose of a compound of formula (I)
- wherein R1, R2, R3, R4 and R5 are independently from each other any of the following groups:
- R1 is selected from the group consisting of hydrogen, methyl, alkyl with 2 to 6 carbon atoms, acetyl, acyl, and —COR, wherein R is an alkyl group with 2 to 6 carbon atoms;
- R2 is selected from the group consisting of hydrogen, methyl, alkyl with 2 to 6 carbon atoms, acetyl, acyl, and —COR, wherein R is an alkyl group with 2 to 6 carbon atoms;
- R3 is an alkane chain with 4 to 29 carbon atoms;
- R4 is selected from the group consisting of hydrogen, methyl, alkyl with 2 to 6 carbon atoms, isopropyl, isobutyl and tert-butyl;
- and
- R5 is selected from the group consisting of hydrogen, methyl, alkyl with 2 to 6 carbon atoms, isopropyl, isobutyl and tert-butyl.
4 more elements
Dependencies are inferred from the claim text.