Tuberculosis drug based on 4-thioureido-iminomethylpyridinium perchlorate: method of preparation and treatment

A method of treating and preventing pulmonary and extrapulmonary tuberculosis, the method comprising the step of:

• administering a composition in a therapeutically effective amount to a patient in need thereof,
• wherein the composition comprises:
• a therapeutically safe and effective amount of 4-thioureido-iminomethylpyridinium perchlorate or a combination of 4-thioureido-iminomethylpyridinium perchlorate and other anti-tubercular drugs;
• wherein 4-thioureido-iminomethylpyridinium perchlorate is in an amount of 8.0% to 90.0% w/w;
• and
• a combination of pharmaceutically acceptable excipients;
• colloidal silicon dioxide in an amount of 0.56% to 5.1% w/w;
• crosspovidone in an amount of 1.94% to 17.9% w/w;
• magnesium stearate in an amount of 0.28% to 2.59% w/w;
• povidone in an amount of 0.56% to 5.1% w/w;
• microcrystalline cellulose in an amount of 6.66% to 61.3% w/w;
• wherein the amounts are percent by weight of the pharmaceutical composition.