γ-aminobutyric acid (GABA) analogues for the treatment of pain and other disorders
AssigneeNovassay S.A.
InventorsPremji Meghani, Franz Kricek
Life of this patent
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Abstract
A compound of Formula 1 wherein R1 represents hydrogen, halo, a C1-C4 alkyl group, a C1-C4 alkylhalide group, a C1-C4 alkoxy-C2-C4 alkyl group, a C2-C4 alkenyl group, a C2-C4 alkynyl group or a C3-C7 cycloalkyl group; R2 represents or a tautomer thereof; and R3 represents hydrogen, a C1-C4 alkyl group, a C1-C4 alkoxy-C2-C4 alkyl group or a C3-C7 cycloalkyl group; or a pharmaceutically acceptable salt or solvate thereof. Processes to prepare said compounds and novel intermediates are also claimed. Such compound finds utility in treating neuropathic pain and disorders of the central nervous system.
Claims17
A method of administering to a human subject a pharmaceutical composition, the pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of Formula 1
- wherein R1 represents hydrogen, halo, a C1-4 alkyl group, a C1-4 alkylhalide group, a (C1-4 alkoxy)(C2-4 alkyl) group, a C2-4 alkenyl group, a C2-4 alkynyl group or a C3-7 cycloalkyl group;
- R2 represents
- or a tautomer thereof;
- and
- R3 represents hydrogen, a C1-4 alkyl group, a (C1-4 alkoxy)(C2-4 alkyl) group or a C3-7 cycloalkyl group;
- or a pharmaceutically acceptable salt or solvate thereof;
- wherein the method comprises:
- (i) providing the human subject with the pharmaceutical composition, wherein the pharmaceutical composition is in a form for administration to a human subject, the form selected from the group consisting of a capsule, a caplet, a tablet, and a topical ointment;
- (ii) administering the form to the human subject, wherein the administering is selected from the group consisting of orally, rectally, parenterally, and topically;
- and (iii) allowing the compound to bind to an α2δ-1subunit of a voltage-gated calcium channel, wherein the voltage-gated calcium channel is embedded within a cell plasma membrane of the human subject.
Dependencies are inferred from the claim text.