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US 9,750,708 B2Granted
Enterically coated cysteamine, cystamine and derivatives thereof
AssigneeThe Regents of the University of California
InventorsRanjan Dohil, Jerry Schneider
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Abstract
The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects.
Claims15
A composition comprising:
- a delayed and extended release enterically coated cystamine formulation, the formulation comprising:
- a core comprising cystamine and a binder;
- and
- an enteric coating surrounding the core,
- wherein the enteric coating releases the cystamine at a pH of 4.5 or greater and provides a time to Cmax of between 2-4 hours after administration.
2 more elements
Dependencies are inferred from the claim text.