Transpulmonary liposome for controlling drug arrival
AssigneesHirofumi Takeuchi, Otsuka Pharmaceutical Co., Ltd.
InventorsHirofumi Takeuchi, Koji Nakano, Hidekazu Toyobuku
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Abstract
An object of the present invention is to provide a liposome which is excellent in intrapulmonary delivery controllability of drugs or genes and is suited for pulmonary administration. By modifying the surface of a liposome using a terminal hydrophobized polyvinyl alcohol and/or chitosan, retention of drugs or genes encapsulated in the liposome on the surface of lung tissue and transfer of drugs or genes into lung tissue can be properly modulated, and thus in vivo behavior can be controlled.
Claims5
A method for treating a disease of lung tissue, comprising the step of administering to a lung of a patient suffering from the disease of lung tissue and needing fast-transfer of a drug or a gene into the lung tissue a therapeutically effective amount of a liposome preparation for pulmonary administration in which a drug or a gene is encapsulated in a liposome having a liposome membrane surface modified with a chitosan, thereby transferring the drug or the gene to the inside of a lung tissue,
- wherein the liposome contains the chitosan in a proportion of 5 to 250 parts by weight, per 100 parts by weight of a total amount of all constituent components of the liposomal membrane;
- and
- wherein the chitosan has a molecular weight from 100,000 to 150,000 daltons and a degree of deacetylation of 80% to 100%.
Dependencies are inferred from the claim text.