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US 9,750,692 B2Granted
Liposomal vaccine compositions comprising a polysaccharide antigen and a protein adjuvant
AssigneeLipoxen Technologies Limited
InventorsAndrew David Bacon, Gregory Gregoriadis, Peter Laing
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Abstract
A liposomal composition, preferably a vaccine, comprising liposomes formed of liposome forming compounds, containing coentrapped polysaccharide antigen and T-cell dependent protein carrier, such as tetanus toxoid or diphtheria toxin modified to render it non-toxic. The invention is of use in the production of vaccines against Haemophilus influenzae, Streptococcus pneumoniae or Neisseria meningitidis.
Claims19
A liposomal composition comprising one or more polysaccharide antigens and a protein carrier coentrapped within liposomes;
- wherein the one or more polysaccharide antigens are water-soluble;
- wherein the protein carrier has at least one T-cell epitope, a molecular weight in the range of 75 kDa to 400 kDa, and is non-toxic;
- wherein the polysaccharide antigen and protein carrier are non-conjugated;
- and
- wherein the liposomes have an average diameter in the range of 50 nm to 700 nm and are formed from liposome forming compounds that have, in combination, no overall ionic charge and comprise at least one phospholipid.
2 more elements
Dependencies are inferred from the claim text.