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US 9,750,689 B2Granted
Transdermal silicone gel (silogel) compositions and methods of preparation
AssigneeHumco Holding Group, Inc.
InventorJohn Olin Trimble
Life of this patent
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Abstract
A silicone gel (“silogel”) composition used to deliver pharmaceutical products transdermally as well as a method for producing the silogel composition, which may contain up to 80% additive ingredients. Preferred embodiments of the invention may include silogel compositions which provide high viscosity/no separation due to API. They are not temperature-sensitive, have no shear stress from the ointment mill/EMP, have no gumming up/stickiness, and no hardening.
Claims1
A silicone gel composition comprising:
- a hydrophilic silicone copolyol, wherein the hydrophilic silicone copolyol comprises phenyl trimethicone, and wherein the phenyl trimethicone is present in a concentration of about 2.0 weight percent;
- a lipophilic silicone copolyol, wherein the lipophilic silicone copolyol comprises C30-45 dimethicone, and wherein the C30-45 dimethicone is present in a concentration of about 2.50 weight percent;
- a non-ionic oil-in-water (O/W) emulsifier agent, wherein the non-ionic oil-in-water (O/W) emulsifier agent comprises a blend of cetearyl alcohol and ceteareth-20, and wherein the non-ionic oil-in-water (O/W) emulsifier agent is present in a concentration of about 10.00 weight percent;
- a non-ionic water-in-oil (W/O) emulsifier agent, wherein the non-ionic water-in-oil (W/O) emulsifier agent comprises a copolymer of hydroxyethyl acrylate and sodium acryloyldimethyl taurate, and wherein the non-ionic water-in-oil (W/O) emulsifier agent is present in a concentration of about 1.90 weight percent;
- an inorganic hydrocolloid, wherein the inorganic hydrocolloid comprises magnesium aluminum silicate, and wherein the magnesium aluminum silicate is present in a concentration of about 1.50 weight percent;
- an organic hydrocolloid, wherein the organic hydrocolloid comprises hydroxypropyl starch phosphate, and wherein the hydroxypropyl starch phosphate is present in a concentration of about 0.10 weight percent;
- a biocompatible surfactant with phosphatidylcholine, wherein the biocompatible surfactant comprises lecithin, and wherein the lecithin is present in an amount of about 0.33 weight percent;
- a first non-polar solvent, wherein the first non-polar solvent is light mineral oil, and wherein the light mineral oil is present in an amount of about 18 weight percent;
- and
- a second non-polar solvent, wherein the second non-polar solvent is isopropyl palmitate, and wherein the isopropyl palmitate is present in an amount of about 0.33 weight percent.
7 more elements
Dependencies are inferred from the claim text.