Back to results
US 9,750,688 B2Granted
Glucan gels
AssigneeBiotec Pharmacon ASA
InventorsRolf Engstad, Stein-Tore Solem, Dag-Eirik Ramsøy
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeBiotec Pharmacon ASA
InventorsRolf Engstad, Stein-Tore Solem, Dag-Eirik Ramsøy
Estimating the term…
The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 35 to 60° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.
A method of assisting wound or ulcer healing or treating oral mucositis or cancer in a subject in need thereof which comprises administering to said subject a gel glucan product comprising a soluble yeast glucan in aqueous solution at a concentration of 1 to 6%, the glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol, the gel glucan product having a gel to sol melting temperature of 35 to 60° C.
A physical support having applied thereto or impregnated therein, a gel glucan product comprising a soluble yeast glucan in aqueous solution at a concentration of 1 to 6%, the glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol, the gel glucan product having a gel to sol melting temperature of 35 to 60° C.
An in vitro method of proliferation of skin cells which comprises contacting a population of skin cells with a gel glucan product comprising a soluble yeast glucan in aqueous solution at a concentration of 1 to 6%, the glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol, the gel glucan product having a gel to sol melting temperature of 35 to 60° C.
Dependencies are inferred from the claim text.