Devices and methods for the treatment of metabolic disorders

A system for stimulating the release of satiety hormone in a subject, the system comprising:

• a stimulus device having a tissue engaging portion configured to be placed in contact with a target tissue of a gastrointestinal system of the subject;
• a movement device linked with the tissue engaging portion and operable to move the tissue engaging portion, thereby mechanically stimulating the target tissue;
• and
• an anchoring device configured to fasten the stimulus device in a target location at the gastrointestinal system such that the tissue engaging portion engages the target tissue;
• wherein the movement device comprises a pump configured to pump a fluid into at least one inflation chamber formed inside the tissue engaging portion, thereby deforming the tissue engaging portion.