Systems and methods for heart valve therapy

A mitral valve replacement system for a heart, comprising:

• an expandable anchor assembly configured to implant at a native mitral valve, the expandable anchor assembly including a first expandable frame that is adjustable from a delivery condition to an expanded condition;
• a first delivery sheath device having a distal end insertable into a left atrium and being configured to express the anchor assembly out from the distal end such that the anchor assembly expands within the left atrium to the expanded condition;
• a pusher instrument releasably attachable to the first expandable frame and being configured to longitudinally advance the anchor assembly within the left atrium towards an annulus of the native mitral valve while the anchor assembly is in the expanded condition;
• an anchor assembly control wire slidably disposable within the first delivery sheath device, wherein the anchor assembly control wire is coupled with the anchor assembly;
• and
• an artificial valve assembly comprising a second expandable frame that is adjustable from a compressed condition to a deployed condition to selectively engage with the anchor assembly while the anchor assembly is in the expanded condition.

A mitral valve replacement system for a heart, comprising:

• an expandable anchor assembly configured to implant at a native mitral valve, the expandable anchor assembly including a first expandable frame that is adjustable from a delivery condition to an expanded condition;
• a first delivery sheath device having a distal end insertable into a left atrium and being configured to express the anchor assembly out from the distal end such that the anchor assembly expands within the left atrium to the expanded condition;
• a pusher instrument releasably attachable to the first expandable frame and being configured to longitudinally advance the anchor assembly within the left atrium towards an annulus of the native mitral valve while the anchor assembly is in the expanded condition;
• a secondary deflectable catheter slidably disposed between the first delivery sheath device and the pusher instrument;
• and
• an artificial valve assembly comprising a second expandable frame that is adjustable from a compressed condition to a deployed condition to selectively engage with the anchor assembly while the anchor assembly is in the expanded condition.

An implantable medical device delivery system comprising:

• a first deflectable catheter defining a first lumen therethrough, wherein a distal end portion of the first deflectable catheter is controllably laterally deflectable;
• a first device delivery sheath slidably disposable within the first lumen, the first device delivery sheath defining a second lumen therethrough;
• a first device control sheath slidably disposable within the second lumen, the first device control sheath defining a third lumen therethrough and one or more first device control wire lumens;
• a second deflectable catheter slidably disposable within the third lumen, the second deflectable catheter defining a fourth lumen therethrough, wherein a distal end portion of the second deflectable catheter is controllably laterally deflectable;
• and
• a device pusher catheter slidably disposable within the fourth lumen, the device pusher catheter defining a fifth lumen therethrough, a distal end portion of the device pusher catheter configured to releasably couple with a first implantable medical device.