Systems and methods for measurement of tissue perfusion

A method comprising the steps of:

• receiving, by a system comprising a processor, an ultrasound signal response of a contrast agent within a volume of tissue as a function of time, wherein the contrast agent is infused into a patient's vasculature at a constant rate, wherein the volume of tissue comprises a geometry, wherein the geometry is a rectangular prism with a corresponding length, width, and height;
• determining, by the system, a probabilistic constant based on the geometry of the volume of the tissue;
• determining, by the system, a ratio of mean velocity to mean path length based on the ultrasound signal response at a first time representing a transitory intensity and a second time representing a steady state intensity;
• determining, by the system, a tissue density of the volume of the tissue;
• and
• determining, by the system, a mean perfusion through the volume of tissue based on the probabilistic constant, the ratio of mean velocity to mean path length, the tissue density, the width, and the height.

A non-transitory computer-readable medium having stored thereon instructions that, upon execution, cause a processor of one or more computing devices to perform operations, the operations comprising:

• receiving an ultrasound signal response of a contrast agent within a volume of tissue as a function of time, wherein the contrast agent is infused into a patient's vasculature at a constant rate, wherein the volume of tissue comprises a geometry, wherein the geometry is a rectangular prism with a corresponding length, width, and height;
• determining a probabilistic constant based on to the geometry of the volume of the tissue;
• determining a ratio of mean velocity to mean path length based on the ultrasound signal response at a first time representing a transitory intensity and a second time representing a steady state intensity;
• and
• determining a mean perfusion through the volume of tissue based on the probabilistic constant, the ratio of mean velocity to mean path length, the tissue density, the width, and the height.